Stanford Experts Uncover That Including a Particular Seafood to Your Diet program Can Reverse Signs of Growing old

Scientists uncovered that supplementing a diet plan with the sea organisms Ascidiacea, also known as sea squirts, reverses some of the key symptoms of ageing in an animal model.

Supplementing your food plan with the sea organisms Ascidiacea, also regarded as sea squirts, reverses some of the main indicators of getting old, in accordance to a new examine applying an animal model.

Whilst the Fountain of Youth, the mythical spring that restores youth to any one who bathes in it or beverages its waters, is evidently fantasy, researchers are tough at get the job done seeking for strategies to battle getting old. Some of these experts just had a breakthrough: they found that supplementing a eating plan with sea squirts, reverses some of the primary indications of getting older.

Though far more analysis is wanted to validate the outcome in people, as the analyze was done utilizing mice, the findings are extremely promising.

If you’ve at any time glanced in the mirror and observed greying hair and wrinkles, or if you have overlooked the identify of a shut buddy, you could want a medicine that might halt or even reverse the consequences of growing older.

In accordance to a new examine, this may possibly not be these types of a foolish notion. Scientists from Xi’an Jiaotong-Liverpool College, Stanford University, Shanghai Jiao tong College, and the College of Chinese Academy of Sciences discovered that supplementing a diet plan with the sea organism Ascidiacea, also identified as sea squirts, reverses some of the principal indicators of growing old in an animal design.

Sea Squirts Anti Aging

Sea squirts can be eaten uncooked and are located in dishes from Korea (in which it is acknowledged as meongge, or 멍게) and Japan (hoya, or ホヤ). Credit: Jpatokal

Sea squirts may well be eaten uncooked and can be observed in recipes from Korea (wherever it is identified as meongge, or 멍게) and Japan (hoya, or ホヤ). These aquatic critters consist of plasmalogens, which are vital to human physique processes. Plasmalogens are the natural way discovered during our bodies, notably in the heart, brain, and immune cells, but the amount in our bodies declines as we age. This loss is also a characteristic of many neurodegenerative illnesses, including

This study is the first to show, in detail, how plasmalogens affect the aging brain.

Sea Squirts

The sea organisms Ascidiacea, also called sea squirts, contain substances called plasmalogens, which are vital to our body processes. Credit: Prilfish

Making new connections

The effects of the plasmalogen supplement on learning and memory were evaluated by training mice to navigate a Morris water maze, which consists of a pool of water with a platform that acts as a resting place. Mice typically dislike swimming, so after five days of training, they remember where the platform is and swim directly to it as soon as they enter the pool. Older mice, on the other hand, take longer to locate the platform following the same amount of training.

Astonishingly, when fed with plasmalogens, aged mice perform more like young mice, finding the platform much quicker than the control group of aged mice that have not been given the supplement.

To find the reason for the improvement shown by plasmalogen-fed mice, the researchers took a closer look at changes happening within the brain. They found that mice that were fed the plasmalogen supplement had a higher number and quality of synapses – the connections between neurons – than the aged mice not given the supplements.

Sea Squirts Improve Learning and Memory in Mice

Aged mice showed improved learning and memory when fed with plasmalogen supplements from Ascidiacea – also known as sea squirts. In this study, mice were trained to find a hidden platform in a pool of water (Morris water maze), and the image shows the paths they took to reach the platform. After five days of training, young mice were able to remember the platform’s location, whereas aged mice took longer and swam further to reach the platform as they forgot its location. However, when fed a plasmalogen supplement, the aged mice took a shorter, quicker route to the platform than those not given the supplement – suggesting improved cognitive function. Credit: Lei Fu

Synapses are a fundamental part of our neural networks and, therefore, crucial for learning and memory. Our synapses tend to be very plastic as children, but they decrease in number and deteriorate with age and in neurogenerative diseases, resulting in cognitive impairments.

Accordingly, in this study, the aged mice fed with plasmalogen supplements showed greater potential for learning new skills and creating new neural networks than the aged mice whose diet was not supplemented. This suggests that dietary plasmalogens can halt the age-related deterioration of synapses.

A further characteristic of getting older, and thought to be a significant factor in neurodegeneration, is inflammation in the brain. Too much inflammation can have a negative effect on cognitive ability, as the brain’s immune system becomes overactive and turns on itself, attacking neurons and preventing synapses from functioning correctly.

In this study, the inflammation in aged mice was greatly decreased in those given plasmalogen supplements compared to those on a normal diet, providing some insight as to why they performed better in learning and memory tasks.

Ascidiae Seescheiden

There are many varieties of sea squirts (Ascidiae). Some are shown in Ernst Haeckel’s Kunstformen der Natur (1904). Credit: Ernst Haeckel

Possible pathways of action

Although it is still unclear how dietary plasmalogen supplements seem to cause such significant changes in learning and memory, Professor Fu speculates on possible pathways of action.

“We found that plasmalogens significantly increase the number of molecules that aid the growth and development of neurons and synapses in the brain. This suggests that plasmalogens can promote neuroregeneration.

“There is also an increasing body of evidence that plasmalogens directly affect the structural properties of synapses. Plasmalogens may increase the fluidity and flexibility of synaptic membranes, affecting the transmission of impulses between neurons.”

Additionally, Professor Fu explains that plasmalogens may also have indirect effects on our brains.

“Some studies have shown that dietary plasmalogens affect the microorganisms in the gut. It has been widely reported that the connection between the organisms in our gut and our brain influences neurodegeneration. It may be the plasmalogen’s effect on this connection that causes the improvements in learning and memory are seen in this study.”

Professor Fu is so convinced by the results of this study that he takes a plasmalogen supplement each day.

“For the first time, we show that plasmalogen supplements might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.

“The oral intake of plasmalogens could be a feasible therapeutic strategy to improve cognitive function in older people.”

So, it could be that a pill to keep you young may not be such an unrealistic proposition after all – as long as it contains sea squirts.

Reference: “Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice” by Jinxin Gu, Lixue Chen, Ran Sun, Jie-Li Wang, Juntao Wang, Yingjun Lin, Shuwen Lei, Yang Zhang, Dan Lv, Faqin Jiang, Yuru Deng, James P. Collman and Lei Fu, 23 February 2022, Frontiers in Molecular Biosciences.
DOI: 10.3389/fmolb.2022.815320